Publications

Articles

  1. Earl D.C., Ferrell P.B. Jr, Leelatian N., Froese J.T., Reisman B.J., Irish J.M., Bachmann B.O. Discovery of human cell selective effector molecules using single cell multiplexed activity metabolomics. Nature Communications, 2018, 9(1),39 DOI
  2. Covington B.C., McLean J.A., Bachmann B.O. Comparative mass spectrometry-based metabolomics strategies for the investigation of microbial secondary metabolites. Natural Products Reports, 2017, 34, 6-24. DOI
  3. Masuyer G, Cozier GE, Kramer GJ, Bachmann BO, Acharya KR., Crystal structure of a peptidyl-dipeptidase K-26-DCP from Actinomycete in complex with its natural inhibitor.FEBS J., 2016, 83, 4357-4369. DOI
  4. Bachmann, B.O., Applied evolutionary theories for engineering of secondary metabolic pathways. Current Opinions in Chemical Biology, 2016, 35, 133-14. DOI
  5. Chong K.M., Leelatian N., Deguire S.M., Brockman A.A., Earl D., Ihrie R.A., Irish J.M., Bachmann B.O., Sulikowski G.A. The use of fluorescently-tagged apoptolidins in cellular uptake and response studies. Journal of Antibiotics. 2016, 69, 327-30. DOI
  6. Tianero MD, Pierce E, Raghuraman S, Sardar D, McIntosh JA, Heemstra JR, Schonrock Z, Covington BC, Maschek JA, Cox JE, Bachmann BO, Olivera BM, Ruffner DE, Schmidt EW. Metabolic model for diversity-generating biosynthesis. Proceedings of the National Academy of Sciences. 2016,113, 1772-7 DOI
  7. Sartor, L. Ibarra, C., Al-Mestarihi A., Bachmann B.O., Vey J. X-ray crystal structure of DnmZ, a nitrososynthase in the Streptomyces peucetius anthracycline biosynthetic pathway. Acta Crystallographica Section F, 2015, 71:1205-14. DOI
  8. McCulloch, K.M., McCranie, E.K., Smith, J.A., Sarwar, M., Mathieu, J.L., Gitschlag, B.L., Du, Y., Bachmann, B.O., Iverson, T.M., Oxidative cyclizations in orthosomycin biosynthesis expand the known chemistry of oxidase superfamily. Proceedings of the National Academy of Sciences, 2015, 112, 11547-52. DOI
  9. Derewacz, D.K., Covington B.C., McLean, J.A., Bachmann, B.O. Mapping microbial response metabolomes for induced natural product discovery. ACS Chemical Biology, 2015, 10(9):1998-2006 DOI
  10. Goodwin C. R., Covington B. C., Derewacz D. K., McNees C. R., Wikswo J. P., McLean J. A., Bachmann B. O. Structuring microbial metabolic responses to multiplexed stimuli via self-organizing metabolomics maps. Chemistry & Biology. 2015, 22, 661-670 DOI
  11. DeGuire S. M., Earl D. C., Du Y., Crews B. A., Jacobs A. T., Ustione A., Daniel C., Chong K. M., Marnett L. J., Piston D. W., Bachmann B. O., Sulikowski G. AFluorescent probes of the apoptolidins and their utility in cellular localization studies.Angewandte Chemie International Edition. 2015, 54(3), 961-4. DOI.
  12. Stow, S.; Goodwin, C.; Kliman, M.; Bachmann, B. O.; McLean, J; Lybrand, T., 2014. A distance geometry protocol to generate conformations of natural products to structurally interpret ion mobility-mass spectrometry collision cross sections. The Journal of Physical Chemistry, 2014, 118, 13812-20. DOI.
  13. Kramer, G. J., Mohd, A., Schwager, S. L., Masuyer, G., Acharya, K. R., Sturrock, E. D., and Bachmann, B. O. Interkingdom pharmacology of angiotensin-I converting enzyme inhibitor phosphonates produced by actinomycetes. ACS Medicinal Chemistry Letters, 2014 5, 346-351. DOI.
  14. Goodwin, C. R., Sherrod, S. D., Marasco, C. C., Bachmann, B. O., Schramm-Sapyta, N., Wikswo, J. P., McLean, J. A. Phenotypic mapping of metabolic profiles using self-organizing maps of high-dimensional mass spectrometry data. Analytical Chemistry. 2014, 86, 6563-6571. DOI.
  15. Birmingham, W. R ., Starbird, C. A., Panosian, T. D. Nannemann, D. P., Iverson, T. M., Bachmann, B. O. Bioretrosynthetic construction of a didanosine biosynthetic pathway. Nature Chemical Biology. 2014, 10, 392-399. DOI.
  16. McCranie, E. K., Bachmann, B. O. Bioactive oligosaccharide natural products. Natural Products Reports. 2014, Natural Product Reports. 2014, 31, 1026. DOI.
  17.  Derewacz, D. K., McNees, C. R., Scalmani, G., Covington, C. L., Shanmugam, G., Marnett, L. J., Polavarapu P. L., Bachmann, B. O . Structure and stereochemical determination of hypogeamicins from a cave-derived actinomycete. Journal of Natural Products. 2014, 77 (8), 1759–1763 DOI.
  18. Bachmann O., Van Lanen S. G., Baltz R. H. Microbial genome mining for accelerated natural products discovery: Is a renaissance in the making? Journal of Industrial Microbiology and Biotechnology. 2014, 41(2), 175-84. DOI.
  19. Al-Mestarihi, A., Romo, A., Liu, H. W., Bachmann, O. Nitrososynthase-triggered oxidative carbon-carbon bond cleavage in baumycin biosynthesis. Journal of the American Chemical Society. 2013, 135(31),11457-60. DOI.
  20. Derewacz, D. K., Goodwin, C. R., McNees, C. R., McLean, J. A., Bachmann, B. O. Antimicrobial drug resistance affects broad changes in metabolomic phenotype in addition to secondary metabolism. Proceeding of the National Academy of Sciences. 2013, 110, 2336-41. DOI.
  21. Iverson, T. M., Panosian, T. D., Birmingham, W. R, Nannemann, D. P., Bachmann, B. O. Molecular differences between a mutase and a phosphatase: Investigations of the activation step in Bacillus cereus Biochemistry. 2012, 51(9), 1964-75. DOI.
  22. Goodwin, C. R., Fenn, L. S., Derewacz, D. K., Bachmann, B. O., McLean, J. A. Structural mass spectrometry: Rapid methods for separation and analysis of peptide natural products. Nat Prod. 2012, 75(1), 48–53. DOI.
  23. Du, Y., Derewacz, D. K., Deguire, S. M., Teske, J., Ravel, J., Sulikowski, G. A., Bachmann, B. O. Biosynthesis of the apoptolidins in Nocardiopsis FU 40. Tetrahedron. 2011, 67, 6568-75. DOI.
  24. Nannemann, D. P., Birmingham, W. R., Scism, R. A., Bachmann, B. O. Assessing directed evolution methods for the generation of biosynthetic enzymes with potential in drug biosynthesis. Future Medicinal Chemistry. 2011, 3, 809-19. DOI.
  25. Panosian, T. D., Nannemann, D. P., Watkins, G., Phelan, V. V., McDonald, W. H., Wadzinski, B. E., Bachmann, B. O., Iverson, T. M., The Bacillus cereus phosphopentomutase is an alkaline phosphatase family member that exhibits an altered entry point into the catalytic cycle. Journal of Biological Chemistry. 2011, 286, 8043-54. DOI.
  26. Vey, J. L., Al-Mestarihi, A., Hu, Y., Funk, M. A., Bachmann, B. O., Iverson, T. M., Structure and mechanism of ORF36, an amino sugar oxidizing enzyme in everninomicin biosynthesis. 2010, 49, 9306-17. DOI.
  27. Akif, M., Ntai, I., Sturrock, E. D., Isaac, R. E., Bachmann, B. O., Acharya, K. R., Crystal structure of a phosphonotripeptide K-26 in complex with angiotensin converting enzyme homologue (AnCE) from Drosophila melanogaster. Biochemical and Biophysical Research Communications. 2010, 398, 532-6. DOI.
  28. Bachmann, B. O., McNees, R., Melancon, B. J., Ghidu, V. P., Clark, R., Crews, B. C., Deguire, S. M., Marnett, L. J., Sulikowski, G. A., Light-induced isomerization of apoptolidin A leads to inversion of C2-C3 double bond geometry. Organic Letters. 2010, 12, 2944-2947. DOI.
  29. Panosian, T. D., Nannemann, D. P., Bachmann, B. O., Iverson, T. M., Crystallization and preliminary X-ray analysis of a phosphopentomutase from Bacillus cereus. Acta Crystallographica F. 2010, 66, 811-814. DOI.
  30. Du, Y., Gisselberg, J. E., Johnson, J. D., Lee, P. J., Prigge, S. T., Bachmann, B. O., Lactococcus lactis fabH, encoding b-ketoacyl-acyl carrier protein synthase, can be functionally replaced by the Plasmodium falciparum Applied and Environmental Microbiology. 2010, 76, 3959-3966. DOI.
  31. Nannemann, D. P., Kaufmann, K. W., Meiler, J., Bachmann, B. O., Design and directed evolution of a dideoxy purine nucleoside phosphorylase. Protein Engineering Design and Selection. 2010, 23, 607-616. DOI.
  32. Reniere, M. L., Ukpabi, G. N., Harry, S. R., Stec, D. F., Krull, R., Wright, D. W., Bachmann, B. O., Murphy, M. E., Skaar, E. P., The IsdG-family of haem oxygenases degrades haem to a novel chromophore. Molecular Microbiology. 2010, 75, 1529-1538. DOI.
  33. Bachmann, B. O., Biosynthesis: Is it time to go retro? (commentary). Nature Chemical Biology. 2010, 6, 390-393. DOI.
  34. Carter, M. D., Phelan, V. V., Sandlin, R. D., Bachmann, B. O., Wright, D. W., Lipophilic mediated assays for b-hematin inhibitors. Combinatorial Chemistry & High Throughput Screening. 2010, 13, 285-292. DOI.
  35. Scism, R. A., Bachmann, B. O., Five-component cascade synthesis of nucleotide analogues in an engineered self-immobilized enzyme aggregate. 2010, 11, 67-70. DOI.
  36. Phelan, V. V., Du, Y., McLean, J. A., Bachmann, B. O., Adenylation enzyme characterization using g –18O4-ATP pyrophosphate exchange. Chemistry & Biology. 2009, 16, 473-478. DOI.
  37. Ghidu, V. P., Ntai, I., Wang, J., Jacobs, A. T., Marnett, L. J., Bachmann, B. O., Sulikowski, G. A., Combined chemical and biosynthetic route to access a new apoptolidin congener. Organic Letters. 2009, 11, 3032-3034. DOI.
  38.  Ntai, I.. Bachmann, B. O., Identification of ACE pharmacophore in the phosphonopeptide metabolite K-26. Bioorganic & Medicinal Chemistry Letters. 2008, 18, 3068-3071. DOI.
  39. Hu, Y., Phelan, V. V., Farnet, C. M., Zazopoulos, E., Bachmann, B. O., Reassembly of anthramycin biosynthetic gene cluster by using recombinogenic cassettes. 2008, 9, 1603-1608. DOI.
  40. Hu, Y., Al-Mestarihi, A., Grimes, C. L., Kahne, D., Bachmann, B. O., A unifying nitrososynthase involved in nitrosugar biosynthesis. Journal of the American Chemical Society. 2008, 130, 15756-15757. DOI.
  41. Scism, R. A., Stec, D. F., Bachmann, B. O., Synthesis of nucleotide analogues by a promiscuous phosphoribosyltransferase. Organic Letters. 2007, 9, 4179-4182. DOI.
  42. Hu, Y., Phelan, V., Ntai, I., Farnet, C. M., Zazopoulos, E., Bachmann, B. O., Benzodiazepine biosynthesis in Streptomyces refuineus. Chemistry and Biology. 2007, 14, 691-701. DOI.
  43. Bachmann, B. O., Foundations for directed alkaloid biosynthesis (commentary). Chemistry and Biology. 2007, 14, 875-876. DOI.
  44. Wilkinson, B., Bachmann, B. O., Biocatalysis in pharmaceutical preparation and alteration. Current Opinion in Chemical Biology. 2006, 10, 169-176. DOI.
  45. Sulikowski, M. M., Bachmann, B. O., Designing a curriculum that goes beyond a list of topics (commentary). ACS Chemical Biology. 2006, 1, 489-491. DOI.
  46. Ntai, I., Phelan, V. V., Bachmann, B. O., Phosphonopeptide K-26 biosynthetic intermediates in Astrosporangium hypotensionis. Chemical Communications. 2006, 4518-4520. DOI.
  47. Ntai, I., Manier, M. L., Hachey, D. L., Bachmann, B. O., Biosynthetic origins of C-P bond containing tripeptide K-26. Organic Letters. 2005, 7, 2763-2765. DOI.
  48. Bachmann, B. O., Decoding chemical structures from genomes (commentary). Nature Chemical Biology. 2005, 1, 244-245. (Commentary). DOI.