Brian Bachmann

Professor Bachmann is Principal Investigator of the Laboratory for Biosynthetic Studies, a multidisciplinary group working on the construction and deconstruction of biosynthetic pathways and the discovery of their products. The broad goals of this group are to investigate how natural product biosynthetic enzymes evolve and to understand the design rules for their concatenation into efficient “total syntheses” of natural products. Can we apply these rules and direct the evolution of these pathways into new biosynthetic pathways of our own design?

The impacts of this work include providing new avenues for drug discovery by combinatorial biosynthesis and “green” cost-effective ways of producing high-value products and intermediates for pharmaceutical and life sciences. A list of his Vanderbilt publications can be found here.

Prior to arriving at Vanderbilt University, Professor Bachmann was Director of Chemistry at Ecopia Biosciences, a natural product-based drug discovery company in Montreal, Quebec. Professor Bachmann has served as a scientific consultant for multiple corporations, and as a Board of Directors member. He holds several U.S. and international publications and patents.

In the Press

Kurtweil News: The bioretrosynthesis solution.

NIGMS Findings Magazine article:  Drugs Deep Down.

Caving for Cures, a short documentary with the LBS and Hazel Barton, produced by the American Museum of Natural History and exhibited in their Hall of Biodiversity in New York. Caving for Cures.

HBO’s VICE News piece on with LBS and the antibiotic crisis.

Popular Science:Bacteria ‘Fight Club’ Could Help Find New Cures For Diseases

Chemical and Engineering News: Bacterial Fight Club Produces New Metabolites