The Vanderbilt Laboratory for Biosynthetic Studies
We study and harness the biosynthetic capabilities of living systems in order to radically accelerate the discovery of new bioactive compounds, and revolutionize how molecules are synthesized.
Exploring the precise choreographies of life’s molecular genetic blueprints, to the enzymes they encode, to the concerted action of scores of enzymes, to manufacture secondary metabolites in vivo. By taking pathways apart, we understand them, and enable the ambitious goal putting novel pathways together.
In applying what we have learned from the study of the blueprints of life, we can now engineer microorganisms to synthesize compounds that have value to medicine. This includes engineering microorganisms to manufacture currently “non-natural” compounds such as AIDS drugs and anticancer compounds.
Biosynthesis for Discovery
Fully 60 – 70% of drugs used in treatment of human illness are either natural products, derived from natural products or can trace their origins to a secondary metabolite. We are exploring extreme environments, specifically caves, for biodiversity capable of producing new natural products for treating human illness.
Brian Bachmann is Associate Professor at the Vanderbilt University Department of Chemistry. He earned his B.S. in Chemistry from Virginia Tech, M.S. from Southern Methodist University, and Ph.D from the Johns Hopkins University.
The VLBS, directed by Brian Bachmann, is an interdisciplinary group of researchers with diverse backgrounds in chemistry, biochemistry, and molecular biology. Researchers from the VLBS have generated foundational advances in natural product biosynthesis, synthetic biology and discovery.
Looking for more information? The Laboratory for Biosynthetic Studies is always on the lookout for new co-workers. Check out the instructions for applying for a position.